Comparison of Treatment of Recurrent HCC With Repeat Hepatectomy,and TACE With AFP Conversion (HCCTACEAFP)

Naval Military Medical University (Second Military Medical University)

Status: Completed

Conditions: Recurrent Hepatocellular Carcinoma

Treatments: Procedure: Hepatectomy; Procedure: TACE

Study type: Interventional

Funder types: Other

Identifiers

NCT02728219

2012ZX10002016007002

Details and patient eligibility

About

The purpose of this study is to compare the treatment of recurrent hepatocellular carcinoma with repeat hepatectomy,and transcatheter arterial chemoembolization (TACE) with AFP conversion.

Full description

Though many HCC patients have been benefited from hepatectomy treatment, still the high recurrence rate after the hepatectomy led to limited effectiveness.

This is the first study in same case system on comparison of effectiveness among repeat hepatectomy, and TACE with AFP conversion.

Enrollment: 150 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. via clinical diagnosis and confirm it is early recurrent liver cancer with AFP conversion, and not accept any anticancer treatment.
2. age:18-70years
3. better liver function (Child-Pugh，class A or B)

Exclusion criteria

1. reject to attend；
2. impossible to come to our hospital for physical examination regularly.
3. cancer epitome、seed focus、lymph node or distant metastasis
4. Blood clotting function hindrance;
5. serious heart、lung、kidney disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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150 participants in 2 patient groups

hepatectomy

Experimental group

Description:

Comparison of Treatment of recurrent hepatocellular carcinoma with repeat hepatectomy,and transcatheter arterial chemoembolization (TACE) with AFP conversion

Treatment:

Procedure: TACE

TACE

Active Comparator group

Treatment:

Procedure: Hepatectomy