Comparison of Treatment Outcome and Cost-effectiveness for GERD

Sungsoo Park

Status: Unknown

Conditions: Gastroesophageal Reflux

Study type: Observational

Funder types: Other

Identifiers

NCT03661151

GERD-PPI-ARS

Details and patient eligibility

About

This study was designed to evaluate the effectiveness of laparoscopic antireflux surgery for treatment of gastroesophageal reflux disease (GERD) comparing with that of non-surgical treatment.

Full description

To treat GERD, the most patients with GERD are managed with acid suppressive medication first, and followed by antireflux surgery when the medical therapy is not effective or when the patient prefer surgery to quit the medicine.

This study has a single cohort in which the patient has the past history of GERD and medical treatment with proton pump inhibitors, and has scheduled to have laparoscopic antireflux surgery for treatment of GERD.

Treatment outcome of surgery will be evaluated comparing with the outcome of medical treatment before registration.

Enrollment: 100 estimated patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Objectively diagnosed GERD
• Past history of medical treatment with PPI more than 8 weeks at any time before antireflux surgery
• Patients scheduled to undergo antireflux surgery to treat GERD

Exclusion criteria

• Other pathologic condition in upper gastrointestinal tract which needs surgical treatment
• No (or less than 8 weeks) past history of acid suppressive medical therapy with PPI
• Patients who underwent endoscopic antireflux procedure

Trial design

100 participants in 1 patient group

Antireflux surgery following PPI

Description:

A single cohort with the GERD patients who had acid suppressive medication with proton pump inhibitor (PPI) followed by laparoscopic antireflux surgery