Comparison of Triglyceride-Glucose Index and Atherogenic Indices Between Patients With Lipedema and Obese Controls

Istanbul Physical Medicine Rehabilitation Training and Research Hospital

Status

Completed

Conditions

Lipedema

Treatments

Other: No intervention

Study type

Observational

Funder types

Other

Identifiers

NCT07240298

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Details and patient eligibility

About

Women aged 18-75 years with a clinical diagnosis of lipedema and an obese control group will be included in the study. Sociodemographic and clinical data (age, height, weight, medications, etc.) of the participants will be recorded. For laboratory evaluation, fasting blood test results obtained within the last three months (including fasting glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycerides) will be used. Based on these parameters, metabolic and atherogenic risk indicators such as the Triglyceride-Glucose Index (TyG), TyG-BMI, Atherogenic Index of Plasma (AIP), Atherogenic Coefficient (AC), Castelli Risk Index I (CRI-I), and Castelli Risk Index II (CRI-II) will be calculated. No additional biochemical tests will be collected from participants; analyses will be performed using existing laboratory results.

Enrollment

140 patients

Sex

Female

Ages

18 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Clinically diagnosed with lipedema
Obese control group with BMI ≥30 kg/m² who do not meet lipedema criteria
Aged between 18 and 75 years
Availability of fasting lipid profile and fasting glucose tests within the past 3 months
Provided voluntary informed consent

Exclusion criteria

Use of medications that routinely affect lipid or glucose metabolism: statins, fibrates, niacin, ezetimibe, high-dose omega-3 supplements, GLP-1 receptor agonists, SGLT2 inhibitors, or systemic corticosteroids (regular use within the past 3 months)
Presence of rheumatologic diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus) or active malignancy
Neurological disorders (e.g., polyneuropathy, multiple sclerosis, history of stroke)
Pregnancy or lactation
History of lower extremity surgery or major trauma within the past 6 months
Received injection therapy or physical therapy for the lower extremities within the past 6 months
Active infection or dermatological disease affecting the lower extremities
History of significant venous insufficiency or acute deep vein thrombosis (DVT)
Alcohol or substance abuse
Smoking