Comparison of TUSP Versus TURP for Treatment of Benign Prostatic Hyperplasia in a Small Prostate Volume

Zhejiang University

Status: Unknown

Conditions: Benign Prostatic Hyperplasia

Treatments: Procedure: TURP; Procedure: TUSP

Study type: Interventional

Funder types: Other

Identifiers

NCT04912349

2020-525

Details and patient eligibility

About

Comparison of transurethral split of the prostate versus transurethral resection of the prostate for treatment of benign prostatic hyperplasia in a small prostate volume: A prospective controlled study

Full description

Transurethral resection of the prostate (TURP) was considered as the golden standard to treat benign prostatic hyperplasia (BPH) for decades. However, TURP was associated with low efficiency to alleviate the lower urinary tract symptoms and a significantly higher risk of bladder neck contracture (BNC) for patients with small-volume BPH. We aimed to compare the therapeutic effect of transurethral split of the prostate (TUSP) with TURP for patients with small-volume BPH (<30 ml).

In this study, some selected small-volume BPH patients were randomly divided into two groups (TUSP and TURP group). The patient's baseline characteristics and perioperative outcomes were recorded. The follow-up was made at 6 months, 1 year and 2 years after surgical treatment.

Enrollment: 150 estimated patients

Sex: Male

Ages: 35 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Benign prostatic hyperplasia patients with surgical indication
• Maximum flow rate <12ml/s
• Prostate volume <30ml
• The international prostate symptoms score>21
• Medication of α-adrenergic blockers for at least 3 months

Exclusion criteria

• Acute prostatitis and urethritis
• Neurogenic bladder
• Abnormal prostate-specific antigen level
• Urethral injury history

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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150 participants in 2 patient groups

Test Group

Experimental group

Description:

Patients received the transurethral split of the prostate(TUSP) treatment.

Treatment:

Procedure: TUSP

Control Group

Active Comparator group

Description:

Patients received the transurethral resection of the prostate(TURP) treatment.

Treatment:

Procedure: TURP