Comparison of Two Different Preload Targets of Stroke Volume Variation During Kidney Transplantation

Seoul National University

Status: Completed

Conditions: Kidney Transplant; Complications; Renal Failure Chronic

Treatments: Other: Crystalloid fluid administration with the target of stroke volume variation ≤ 12%; Other: Crystalloid fluid administration with the target of stroke volume variation ≤ 6%

Study type: Interventional

Funder types: Other

Identifiers

NCT03949036

1811-028-983

Details and patient eligibility

About

The investigators sought to compare the effect of two preload targets of stroke volume variation of ≤6% and ≤12% on the postoperative renal function in patients undergoing living donor kidney transplantation. Goal-directed fluid therapy will be performed in both groups to maintain adequate stroke volume, stroke volume variation, mean arterial pressure (or systemic vascular resistance) during kidney transplantation. Only the preload target for giving crystalloid during surgery will be different between groups.

Full description

The adequate preload target of fluid management has not yet been established during kidney transplantation. Traditionally, sufficient intravascular volume status has been recommended to maintain perfusion to renal graft. Stroke volume variation was reported to be superior to the traditional target of central venous pressure. In this regard, the investigators sought to compare the effect of two preload targets of stroke volume variation of ≤6% and ≤12% on the postoperative renal function in patients undergoing living donor kidney transplantation. Goal-directed fluid therapy will be performed in both groups to maintain adequate stroke volume, stroke volume variation, mean arterial pressure (or systemic vascular resistance) during kidney transplantation. Only the preload target for giving crystalloid during surgery will be different between groups.

Enrollment: 60 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults patients who are undergoing living donor kidney transplantation with continuous radial artery pressure monitoring

Exclusion criteria

• Patients who have cardiac arrhythmia of atrial fibrillation, multiple ventricular premature complex
• Cardiac systolic dysfunction with left ventricle ejection fraction <50%
• Continuous arterial pressure monitoring at the site other than radial artery.
• Patients who are considered to be intolerant to rapid fluid administration

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

60 participants in 2 patient groups

target of Stroke Volume Variation ≤ 6%

Experimental group

Description:

The rate of intraoperative fluid administration will be adjusted to achieve the target of Stroke Volume Variation ≤ 6%. A crystalloid bolus of 200 ml will be repeatedly administered every 20 min until the target was achieved. The basal rate of fluid administration will be 3 ml/kg/hr.

Treatment:

Other: Crystalloid fluid administration with the target of stroke volume variation ≤ 6%

target of Stroke Volume Variation ≤ 12%

Active Comparator group

Description:

The rate of intraoperative fluid administration will be adjusted to achieve the target of Stroke Volume Variation ≤ 12%. A crystalloid bolus of 200 ml will be repeatedly administered every 20 min until the target was achieved. The basal rate of fluid administration will be 3 ml/kg/hr.

Treatment:

Other: Crystalloid fluid administration with the target of stroke volume variation ≤ 12%