Comparison of Two Dosages of Heparin Before Extracorporeal Circulation

Astes

Status and phase: Completed; Phase 4

Conditions: Extracorporeal Circulation; Complications

Treatments: Diagnostic Test: ACT (Activated Clotting Time); Drug: Heparin

Study type: Interventional

Funder types: Other

Identifiers

NCT03752437

MDKR

Details and patient eligibility

About

In this study the investigators will study two dosages of heparin before extracorporeal circulation in open chest cardiac surgery.

Full description

In this study the investigators will study two dosages of heparin before extracorporeal circulation in open chest cardiac surgery. The first dosage will be 300 IU per kilogram of REAL weight, the second dosage will be 300 IU per kilogram of IDEAL weight.

Enrollment: 150 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients admitted for cardiac open chest surgery

Exclusion criteria

• Patient's refusal
• Antithrombin III factor < 75%
• Patient under treatment by heparin IV

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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150 participants in 2 patient groups

Real Weight

Experimental group

Description:

Injection of 300 IU of heparin based on REAL weight. This injection will be controlled by an ACT (activated clotting time) one minute after the injection.

Treatment:

Diagnostic Test: ACT (Activated Clotting Time)

Drug: Heparin

Ideal Weight

Experimental group

Description:

Injection of 300 IU of heparin based on IDEAL weight. This injection will be controlled by an ACT (activated clotting time) one minute after the injection.

Treatment:

Diagnostic Test: ACT (Activated Clotting Time)

Drug: Heparin