Comparison of Two Empirical Antimicrobial Therapies of Prosthetic Joint Infection

Civil Hospices of Lyon

Status: Completed

Conditions: Bone and Joint Infection

Treatments: Other: empirical antibiotherapy

Study type: Observational

Funder types: Other

Identifiers

NCT03850860

18-326

Details and patient eligibility

About

The empirical use of vancomycin in combination with a broad-spectrum beta-lactam is currently recommended after the initial surgery of prosthetic joint infection (PJI). However, the tolerability of such high-dose intravenous regimens is poorly known. T

Full description

The empirical use of vancomycin in combination with a broad-spectrum beta-lactam is currently recommended after the initial surgery of prosthetic joint infection (PJI). However, the tolerability of such high-dose intravenous regimens is poorly known. The empirical antimicrobial therapy of PJI is associated with an important rate of adverse, linked with the use of the vancomycin and the piperacillin-tazobactam combination. Some studies suggest to use vancomycin-cefepime, which remains to be evaluated in PJI.

Enrollment: 178 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients having had a prosthetic joint infection and having had a postoperative empirical antibiotherapy with combination of vancomycine and piperacillin-tazobactam or vancomycine and cefepime

Exclusion criteria

• none

Trial design

178 participants in 2 patient groups

empirical antibotherapy currently used

Description:

patients having had a vancomycin and piperacillin-tazobactam combination as empirical antibiotherapy

Treatment:

Other: empirical antibiotherapy

another empirical antibotherapy

Description:

patients having had a vancomycin and cefepime combination as empirical antibiotherapy

Treatment:

Other: empirical antibiotherapy