Comparison of Two Method Antimetabolites Application on Corneal Function in Trabeculectomy Surgery

S

Shahid Beheshti University of Medical Sciences

Status and phase

Unknown
Phase 2

Conditions

Glaucoma Patients Scheduled for Trabeculectomy

Treatments

Drug: Mitomycin_c

Study type

Interventional

Funder types

Other

Identifiers

NCT01297803
8772

Details and patient eligibility

About

Application of antimetabolite agents such as mitomycin_c has improved trabeculectomy results and better control of intraocular pressure complications such as corneal endothelial cell loss. However, Mitomycin_c can be applied remain a concern before or after sclera flap dissection. Mitomycin_c application after sclera flap dissection probably increases corneal endothelial cell loss. This study compares Mitomycin_c application two methods: before and after sclera flap dissection with regard to success rate and complication. patients on base of Mitomycin_c application time (1-2-3) minutes will be match randomise in to two groups( before and after sclera flap dissection) corneal. Endothelial cell density, polymorphism, polymegathism and intraocular pressure before and one month, three months, six months after surgery will measured.

Sex

All

Ages

15 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Age Range between 18 to 80 years old
  • Trabeculectomy to JOAC, POAG, CACG, PXF, pigment dispersion syndrome.

Exclusion criteria

Secondary glaucoma (active uveitis, NVG, specific syndromes such as axenfeld rieger, Iridocorneal Endothelial syndrome, aniridia, peters, etc).

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

0 participants in 2 patient groups

Mitomycin_c application before sclera flap dissection
Active Comparator group
Treatment:
Drug: Mitomycin_c
Mitomycin_c application after sclera flapdissection
Active Comparator group
Treatment:
Drug: Mitomycin_c

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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