Comparison of Two Rehabilitation Programs in Patients With Mild to Moderate Parkinson's Disease. (ASYMOT)

Assistance Publique - Hôpitaux de Paris

Status: Completed

Conditions: Parkinson's Disease

Treatments: Other: Asymmetric Motor Strengthening; Other: Conventional therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT02797496

2009-A00669-48 (Other Identifier)

P071236

Details and patient eligibility

About

Parkinson's disease is a major source of handicap, for which physical treatments are often underutilized with respect to chemical or surgical treatments. Yet, dopaminergic treatments alone prove unable to stop or control the gradual worsening of motor disability after a few years.

The training program that this study sets out to evaluate aims to restore balance between agonist extensors and antagonist flexors in Parkinson's disease.

There is indeed in Parkinson's disease an imbalance between weak flexors and weaker extensors, with excessive predominance of the flexors. The hypothesis of the study is that a motor strengthening program targeting extensor muscles specifically will improve body posture and restore motor function better than a conventional physical therapy program, in mild to moderate Parkinson's disease.

This is a parallel-group, single blind, randomized trial (investigators will be kept unaware of the physical treatment followed by study subjects).

The duration of patient participation is 5 months: 2-month intervention and 3-month follow-up following the intervention.

Enrollment: 39 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

• Patient diagnosed with Parkinson's disease on UKPDSBB criteria.
• Hoehn & Yahr stage 2, 3 in "OFF" state
• Age ≥18 years
• Patient who agreed to sign an informed consent to participate in this study.

Exclusion Criteria

• Patients who cannot or do not wish to follow a motor rehabilitation program for two months with a subsequent follow-up 3 months
• Intercurrent severe condition jeopardizing the vital or functional prognosis or the ability to participate in rehabilitation sessions.
• Cognitive dysfunction making effective communication or participation in a rehabilitation program impossible
• Person not benefiting from French State Health Insurance
• Current participation in another research protocol

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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39 participants in 2 patient groups

Asymmetric Motor Strengthening

Experimental group

Treatment:

Other: Asymmetric Motor Strengthening

Conventional Therapy

Active Comparator group

Treatment:

Other: Conventional therapy