Comparison of Two SpO2 Targets With Two Different Oximeters - Impact on FiO2 During Nasal High Flow Oxygen Therapy

Laval University

Status: Not yet enrolling

Conditions: High Flow Oxygen Therapy; Oxygen Delivery; Acute Respiratory Failure; Hypoxemic Acute Respiratory Failure

Treatments: Device: Manual FiO2 titration with Philips oximeter (SpO2 target 90%); Device: Manual FiO2 titration with Philips oximeter (SpO2 target 94%); Device: Manual FiO2 titration with Nonin oximeter (SpO2 target 90%); Device: Manual FiO2 titration with Nonin oximeter (SpO2 target 94%)

Study type: Interventional

Funder types: Other

Identifiers

NCT07168213

2026-4432

Details and patient eligibility

About

Several factors can influence oxygenation monitoring and respiratory support through oxygen therapy: the type of oximeter used, skin pigmentation, and the oxygenation target. It is essential to have an accurate measurement of SpO2 in order to optimize the flow of oxygen or FiO2 administered to patients. The question arises as to the impact of these confounding factors on the FiO2 set during high-flow nasal oxygen therapy. The aim of the study is to evaluate the impact of the oxygenation target and the oximeter used on FiO2 in patients receiving high-flow nasal oxygen therapy.

Full description

The oximeters evaluated will be the Nonin (Plymouth, MN) and the Philips (Eindhoven, Netherlands). Two SpO2 targets will be evaluated: 90% and 94%.

A total of four 10-minute periods will be performed in randomized order: Nonin 90, Nonin 94, Philips 90, and Philips 94.

At the end of each 10-minute period, arterial gas will be collected through the arterial catheter.

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ≥ 18 years of age
• Admiitted in intensive care unit
• Presence of an arterial catheter
• Ongoing on high flow nasal oxygen therapy with SpO2 between 88 and 100% with a FiO2 between 40 and 80% with the usual oximeter .

Exclusion criteria

• No SpO2 signal with oximeter in use
• False nails or nail polish
• Methemoglobinemia >0.015 on last available arterial gas
• Patient in isolation (multi-resistant bacteria, C-Difficile, SARS-CoV-2 ...)
• Expected to use another respiratory support within two hour of inclusion (NIV or mechanical ventilation)

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Crossover Assignment

Masking: Single Blind

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30 participants in 4 patient groups

Nonin oximeter with a 90% SpO2 target

Experimental group

Description:

During this periods , oxygen through high flow nasal therapy a will be administered in an manual titration to reach 90% of SpO2.

Treatment:

Device: Manual FiO2 titration with Nonin oximeter (SpO2 target 90%)

Philips oximeter with a 90% SpO2 target

Experimental group

Description:

During this periods , oxygen through high flow nasal therapy a will be administered in an manual titration to reach 90% of SpO2.

Treatment:

Device: Manual FiO2 titration with Philips oximeter (SpO2 target 90%)

Nonin oximeter with a 94% SpO2 target

Experimental group

Description:

During this periods , oxygen through high flow nasal therapy a will be administered in an manual titration to reach 94% of SpO2.

Treatment:

Device: Manual FiO2 titration with Nonin oximeter (SpO2 target 94%)

Philips oximeter with a 94% SpO2 target

Experimental group

Description:

During this periods , oxygen through high flow nasal therapy a will be administered in an manual titration to reach 94% of SpO2.

Treatment:

Device: Manual FiO2 titration with Philips oximeter (SpO2 target 94%)