Comparison of Two Types of Family Therapy in the Treatment of Adolescent Anorexia Nervosa

Stanford University

Status and phase: Completed; Phase 3

Conditions: Anorexia Nervosa

Treatments: Behavioral: Systems Family Therapy; Behavioral: Family Behavior Therapy

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00610753

5 U01 MH076290 SPO#33857;

SU-12132007-933

Details and patient eligibility

About

This study will compare the effectiveness of two different family treatments for the treatment of adolescent anorexia nervosa.

Full description

The long-term objective of this study is to enhance the treatment and outcome of anorexia nervosa (AN). Research on the treatment of AN has lagged that of other conditions, even other eating disorders such as bulimia nervosa. The focus of this study is on adolescent AN. Successful early treatment is likely to reduce the prevalence of chronic AN with its high rates of morbidity and mortality and high health care costs. The most promising treatment for adolescent AN is a specific form of family therapy called behavioral family therapy (BFT). This treatment is focused on the disordered eating behavior that characterizes AN and enables parents to refeed their child. Although there have been several small scale studies of BFT there has been no controlled comparison with another form of family therapy. Therefore we propose to use systems family therapy (SFT) which has been developed to represent the type of family therapy practiced in the community.

One hundred and sixty adolescents of both genders aged 12-18 years meeting DSM-IV criteria for anorexia nervosa will be entered to the study. Recruitment is projected to extend for 2 years. Participants will be randomly allocated to one of the two types of family therapy. Family therapy will be given for 36-weeks. For the purpose of the present study, patients will be followed for 12-months after the end of family treatment. Hence, each family will participate for approximately 2-years, with a total participation time of some 40-hours. In a sub-study blood will be drawn from those volunteering for genetic analysis focusing on the subset of non-responders to treatments.

Enrollment: 164 patients

Sex: All

Ages: 12 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:Diagnosis of anorexia nervosa with Ideal Body Weight >75% Exclusion Criteria:Current psychotic illness or mental retardation that would prohibit the use of psychotherapy Medically unstable for outpatient treatment

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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164 participants in 2 patient groups

Family Behavioral Therapy

Experimental group

Description:

This intervention focuses on counseling the parents (and other family members) on refeeding their child. When weight is being steadily regained the focus of therapy shifts to allow the child more independence.

Treatment:

Behavioral: Family Behavior Therapy

Systems Family Therapy

Active Comparator group

Description:

This therapy focuses primarily on clarifying psychological processes within the family.

Treatment:

Behavioral: Systems Family Therapy