Comparison of Vascular Remodeling Between Different Antianginal Medication Evaluated by Noninvasive ECG-gated Fundus Photographic Evaluation

Seoul National University

Status and phase: Unknown; Phase 4

Conditions: Stable Angina

Treatments: Drug: Diltiazem treated group; Drug: Candesartan treated group; Drug: Bisoprolol treated group

Study type: Interventional

Funder types: Other

Identifiers

NCT01162902

ABC Trial

Details and patient eligibility

About

Treatments for stable angina includes drug therapy such as calcium-channel blocker, beta blocker, and ACEI/ARB. To obtain good prognosis in patients with coronary artery disease,preventing or correcting the progression of atherosclerosis and dyslipidemia is more important than relieving angina symptom. Dysfunction of microvessel is one of the most important factor in patients with coronary artery disease. Recently, we developed the new non-invasive method of evaluating the microvessel in fundus. With this methods, we will compare the effect of each drug (beta blocker, CCB, ARB).

Enrollment: 150 estimated patients

Sex: All

Ages: 30 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Stable angina patients whose coronary lesions is confirmed by angiography or receives PCI
• Unstable Angina/NSTEMI patients who completed PCI for main lesions
• Either systolic > 130mmHg or diastolic > 80mmHg, or patients with anti-hypertensive drugs

Exclusion criteria

• STEMI patients within one month
• Variant Angina
• Liver function abnormality or renal failure
• History of Hypersensitivity to testing drugs
• Severe heart failure(NYHA class>3) or uncorrectable hematologic disease
• Woman possible to be pregnant
• Uncontrolled diabetes
• Expected life span < one year

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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150 participants in 3 patient groups

Diltiazem treated group

Experimental group

Description:

Diltiazem 180mg treated group

Treatment:

Drug: Diltiazem treated group

Bisoprolol treated group

Active Comparator group

Description:

Bisoprolol 5mg treated group

Treatment:

Drug: Bisoprolol treated group

Candesartan treated group

Active Comparator group

Description:

Candesartan 32mg treated group

Treatment:

Drug: Candesartan treated group