Comparison of Volume Assist Control, Dual Mode and Airway Pressure Release Ventilation. (COMIX-R)

University Hospital, Angers

Status: Completed

Conditions: ARDS

Treatments: Other: ventilation strategy

Study type: Interventional

Funder types: Other

Identifiers

NCT04196738

49RC19_0195

Details and patient eligibility

About

The aim of the COMIX-R study is to assess the short term physiological effects of 3 ventilation strategies for adult patients with ARDS admitted to intensive care unit

Enrollment: 20 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 years or older
• Invasive mechanical ventilation on tracheal probe
• Acute respiratory distress syndrome, as defined by Berlin conference consensus, during hospitalization in intensive care,
• Recovery phase of acute respiratory distress syndrome: spontaneous ventilation representing from 20 to 30% of ventilation in APRV mode.
• No severe acidosis (pH> 7.30)
• Patient affiliated to or beneficiary of a health care plan
• Express consent of the patient or his/her SDM

Exclusion criteria

• Pneumothorax
• Contraindication to the insertion of a nasogastric tube with an esophageal balloon
• Contraindication to the use of Electrical impedance tomography (pacemaker)
• Pregnancy, lactating or parturient woman

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

Dual Mode first

Experimental group

Description:

Four consecutive steps (45 min per step) in the following order: APRV (A), Dual Mode (B) , APRV (A) and VAC (C). (ABAC)

Treatment:

Other: ventilation strategy

VAC fist

Experimental group

Description:

Four consecutive steps (45 min per step) in the following order: APRV (A), VAC (C) , APRV (A) and Dual Mode (B). (ACAB)

Treatment:

Other: ventilation strategy