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Comparison of Volume Assist Control, Dual Mode and Airway Pressure Release Ventilation. (COMIX-R)

U

University Hospital, Angers

Status

Completed

Conditions

ARDS

Treatments

Other: ventilation strategy

Study type

Interventional

Funder types

Other

Identifiers

NCT04196738
49RC19_0195

Details and patient eligibility

About

The aim of the COMIX-R study is to assess the short term physiological effects of 3 ventilation strategies for adult patients with ARDS admitted to intensive care unit

Enrollment

20 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • 18 years or older
  • Invasive mechanical ventilation on tracheal probe
  • Acute respiratory distress syndrome, as defined by Berlin conference consensus, during hospitalization in intensive care,
  • Recovery phase of acute respiratory distress syndrome: spontaneous ventilation representing from 20 to 30% of ventilation in APRV mode.
  • No severe acidosis (pH> 7.30)
  • Patient affiliated to or beneficiary of a health care plan
  • Express consent of the patient or his/her SDM

Exclusion criteria

  • Pneumothorax
  • Contraindication to the insertion of a nasogastric tube with an esophageal balloon
  • Contraindication to the use of Electrical impedance tomography (pacemaker)
  • Pregnancy, lactating or parturient woman

Trial design

Primary purpose

Other

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

None (Open label)

20 participants in 2 patient groups

Dual Mode first
Experimental group
Description:
Four consecutive steps (45 min per step) in the following order: APRV (A), Dual Mode (B) , APRV (A) and VAC (C). (ABAC)
Treatment:
Other: ventilation strategy
VAC fist
Experimental group
Description:
Four consecutive steps (45 min per step) in the following order: APRV (A), VAC (C) , APRV (A) and Dual Mode (B). (ACAB)
Treatment:
Other: ventilation strategy

Trial contacts and locations

1

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Central trial contact

François BELONCLE, CCU-AH

Data sourced from clinicaltrials.gov

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