Comparison of Whole-body MRI, Circulating DNA and PET-CT in Staging, Prognosis, and Treatment Response in Patients with Diffuse Large Cell B Lymphoma

Charles University, Czech Republic

Status: Completed

Conditions: Lymphoma, Diffuse Large B-Cell

Study type: Observational

Funder types: Other

Identifiers

NCT06777290

12/20 VFN IGP

Details and patient eligibility

About

The aim of the study is to compare the diagnostic performance of whole-body MRI scan, positron emission tomography + CT, and circulating tumor DNA in patients with hematologic malignancy called diffuse large cell B lymphoma (DLBCL) in staging and restaging, and prognosis.

Full description

Patients newly diagnosed with DLBCL or patients with relapsed DLBCL who consent to participate in this study will apart from standard staging and restaging examination with PET/CT undergo whole-body MRI (wbMRI). From blood samples, the level of circulating tumor DNA (ctDNA) fragments will be estimated. These procedures will be repeated during restaging after primary treatment. The diagnostic accuracy of wbMRI in initial staging and restaging will be compared with PET/CT as the gold standard. Circulating tumor DNA levels will be compared at baseline with staging from PET/CT. The change in levels of ctDNA will be compared with the treatement response assessed by PET/CT. All three methods will be used as prognostic indicators.

Enrollment: 14 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age ≥18 years
• performance status according to the Eastern Cooperative Oncology Group between 0 and 3
• satisfactory clinical condition to participate in this study
• adequate hematologic and renal functions
• no contraindications to MRI
• recent or planned PET/CT at the institution
• informed consent to participate.

Exclusion criteria

• history of indolent lymphoma
• anti-lymphoma treatment initiated before PET/CT or wbMRI
• central nervous system lymphoma

Trial design

14 participants in 1 patient group

DLBCL patients

Description:

Adult patients newly diagnosed with diffuse large cell B lymphoma