Comparison of Zometa Retention and Effect in Multiple Myeloma and Breast Cancer

Vejle Hospital

Status and phase

Completed

Phase 2

Conditions

Breast Cancer

Multiple Myeloma

Treatments

Drug: Zoledronic Acid

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT00760370

2007-003777-13

Details and patient eligibility

About

The investigators major aim is to determine whether there is a difference in the retention of zoledronic acid in multiple myeloma patients, compared to patients with breast cancer metastasis to bone. In addition the investigators wish to analyze if the retention of zoledronic acid is correlated to the extent of bone resorption/formation, and if there is a tendency to changes in retention with sequential treatment.

Full description

The clinical benefit from treatment with bisphosphonates has been documented in a large number of clinical studies, and bisphosphonates are now widely used for treatment of pain and prevention of bone fractures or vertebral collapse for example in patients with cancer metastasis to bone or multiple myeloma.

Repeated intravenous administration of the more potent bisphosphonates (pamidronate and zoledronic acid) are often used for treatment of osteolytic disease caused by disseminated cancer or multiple myeloma, while the less potent oral bisphosphonates are often prescribed for treatment of benign osteoporosis. The recommended dose and time schedule for treatment with the more potent bisphosphonates is based on concerns of avoiding toxicity and at the same time obtaining maximal clinical benefit. Clinical studies in multiple myeloma and bone metastasis show significant activity of pamidronate (90 mg by iv infusion during 2-4 hours) or zoledronic acid (4 mg iv during 15 min) repeated every 4 weeks after a treatment period of 9 months and beyond, but the optimal duration of treatment is not known. This is a particular important issue since the use of potent bisphosphonates have been brought in connection with osteonecrosis.

In the present study we will compare the retention of Zometa with the effect on bone markers in patients with multiple myeloma or breast cancer with metastases to bone.

Enrollment

60 patients

Sex

Female

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients diagnosed with breast cancer and metastases to bone.
Patients diagnosed with multiple myeloma.
Patients who are scheduled to receive Zometa.
Post-menopausal women (at least 10 months since last period).
Newly diagnosed patients must have clear signs of osteolysis.

Exclusion criteria

Anti-estrogen treatment.
Patients given chemotherapy during or less than 7 days before study begin.
Patients receiving glucocorticoids less than 5 days prior to study begin or during the study period (14 days)