Comparison on Succinylcholine Onset Time Assessed by Train of Four Stimulation Versus Clinical Judgment During Rapid Sequence Induction of Anesthesia (CELOTOF)

Caen University Hospital

Status: Unknown

Conditions: Aspiration of Gastric Contents Into Respiratory Tract, Part Unspecified; Suxamethonium Sensitivity

Study type: Observational

Funder types: Other

Identifiers

NCT03415607

CELOTOF

Details and patient eligibility

About

Succinylcholine is a myorelaxant agent often used during rapid sequence induction for patients who need to undergo general anesthesia but who are at risk of pulmonary aspiration of gastric content. Whereas other myorelaxant agents are monitored with train of four stimulation to assess onset and duration, few anesthesiologists use train of four stimulation for onset of succinylcholine, as the anesthesiologists evaluate the effect with the time from injection (usually one minute) and the muscle fasciculation due to the release of acetylcholine.

The data available on onset duration of this drug are old and bases on only few studies, but the succinylcholine if sometime harmful (anaphylaxis , cardiac arrest, bronchospasm).

The investigators want to assess the onset time of succinylcholine with an objective toll , the train of four stimulation, and evaluate if the clinical judgment of the anesthesiologist is reliable to predict an adequate moment for endotracheal intubation.

Enrollment: 110 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Every patient undergoing general anesthesia with the use of suxamethonium for induction as assessed by the anesthesiologist

Exclusion criteria

• Patient under 18 years old
• Pregnant woman
• Nasotracheal intubation
• Monitoring of train of four at the adductor pollis impossible (such as patient with no arm )