Comparison the Effects of 3 Different Intraarticular Ketamine Doses on Postoperative Pain.

Balikesir University

Status and phase: Completed; Phase 4

Conditions: Arthroscopy

Treatments: Drug: Ketamine 0.5; Drug: Ketamine 1; Drug: % 0.9 NaCl

Study type: Interventional

Funder types: Other

Identifiers

NCT03955809

osagir3

Details and patient eligibility

About

the aim is to compare the effects of two different doses of intraarticular ketamine on postoperative pain scores and analgesic requirements.in knee artroscopy

Full description

All pateints are going to be operated under general anesthesia. At the end of the study patients are going to be randomyl seperated into 3 groups. The surgeon is going the following drugs intraarticulary.

Group KL1: 0.5 mg/kg ketamin in % 0..9 NaCl at a total volume of 20 ml Group KL2: 1 mg/kg ketamin in % 0.9 NaCl at a total volume of 20 ml Group SL: 20 ml % 0.9 NaCl ll patients are going to receive a periarticula injection of 10 ml 0.5 bupivacaine and patient controlled analgesia with morphine.

VAS scores and total analgesic requirement is going to be evaluated.

Enrollment: 75 patients

Sex

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Artroscopic surgery
• ASA I-II

Exclusion criteria

• Long time NSAID use
• Travmatic knee injury
• Long ter analgesic use
• Intraartiular catheter insertion at the end of surgery

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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75 participants in 3 patient groups

Ketamine 0.5 mg/kg

Active Comparator group

Description:

ketamin 0.5 mg/kg intraarticular

Treatment:

Drug: Ketamine 0.5

Ketamine 1 mg/kg

Active Comparator group

Description:

ketamin 1 mg/kg intraarticular injection

Treatment:

Drug: Ketamine 1

% 0.9 Saline

Sham Comparator group

Description:

% 0.9 NaCL intraarticular injection

Treatment:

Drug: % 0.9 NaCl