Comparison The Postoperative Effects of Local and Systemic Antibiotics Applied With Platelets Rich Fibrin

Ceren Melahat Donmezer

Status: Completed

Conditions: Impacted Wisdom Tooth

Treatments: Drug: Analgesic; Biological: Platelet Rich Fibrin; Procedure: traditional osteotomies; Drug: Antibiotic; Drug: Antibiotics, Penicillin; Diagnostic Test: Diagnosis

Study type: Observational

Funder types: Other

Identifiers

NCT04989127

YDU/2019/67-774

Details and patient eligibility

About

The aim of this study was investigate the comparison of postoperative effects of local antibiotics mixed with platelet-rich fibrin and postoperative systemic antibiotic applications prescribed for mandibular impacted third molar tooth extraction. The study included a total of 75 patients with impacted mandibular third molar. Patients were evaluated in 5 randomly separated groups. For the first and third group, Platelets Rich Fibrin+ systemic Antibiotics were applied into the tooth socket and for the second and fourth group, Platelets Rich Fibrin + local antibiotics were applied, respectively. There was a control group which only Platelets Rich Fibrin was applied into the socket. The outcome variables were pain, swelling, the number of analgesics taken, and trismus. These variables were also assessed based on first, second, third, and seventh days following the operation.

Enrollment: 75 patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• The patient had no systemic diseases, no taken opioids for a long period, no current infections or acute pericoronitis, no smoke or drink alcohol, no pregnancy, the absence of allergy to penicillin and presence of penicillin allergy.

Exclusion criteria

• pericoronitis, no inflammation

Trial design

75 participants in 5 patient groups

group 1

Description:

platelet-rich fibrin placed into the socket of the extracted tooth.+ Augmentin 1 gr tablet prescribed 3 times a day

Treatment:

Diagnostic Test: Diagnosis

Drug: Antibiotics, Penicillin

Drug: Analgesic

Procedure: traditional osteotomies

Biological: Platelet Rich Fibrin

group 2

Description:

platelet-rich fibrin + 0.5 ml amoklavin I.V. 1.2 gr placed into the socket of the extracted tooth.

Treatment:

Diagnostic Test: Diagnosis

Drug: Antibiotics, Penicillin

Drug: Analgesic

Procedure: traditional osteotomies

Biological: Platelet Rich Fibrin

group 3

Description:

platelet-rich fibrin placed into the socket of extracted tooth + Clin 150 mg capsule prescribed 4 times a day

Treatment:

Diagnostic Test: Diagnosis

Drug: Antibiotic

Drug: Analgesic

Procedure: traditional osteotomies

Biological: Platelet Rich Fibrin

group 4

Description:

platelet-rich fibrin + 0.5 ml Clin 600 mg/4 ml IM/IV, 0.5 ml placed into the socket of the extracted tooth.

Treatment:

Diagnostic Test: Diagnosis

Drug: Antibiotic

Drug: Analgesic

Procedure: traditional osteotomies

Biological: Platelet Rich Fibrin

control group

Description:

platelet-rich fibrin placed into the socket of extracted tooth and no antibiotic is prescribed.

Treatment:

Diagnostic Test: Diagnosis

Drug: Analgesic

Procedure: traditional osteotomies

Biological: Platelet Rich Fibrin