ClinicalTrials.Veeva

Menu

Comparisons of iv Ibuprofen and iv Paracetamol During Bariatric Surgery

I

Inonu University

Status and phase

Completed
Phase 4

Conditions

Bariatric Surgery Candidate
Obesity, Morbid

Treatments

Drug: ibuprofen
Drug: paracetamol

Study type

Interventional

Funder types

Other

Identifiers

NCT02778958
Inonu Medicine Faculty

Details and patient eligibility

About

The aim of this study is to evaluate and to compare the effectiveness of iv ibuprofen and iv paracetamol during bariatric surgery.

Full description

Evaluation of effectiveness of iv ibuprofen and iv paracetamol on postoperative pain, opioid consumption, and side effects in morbidly obese patients undergoing bariatric laparoscopic surgery

Enrollment

40 patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients undergoing laparoscopic sleeve gastrectomy and gastric by-pass surgery

Exclusion criteria

  • Hepatic disfunction,
  • Renal failure (creatinine > 3 mg/dL,creatinin clearance < 60 mL/dk or urine out-put < 500 mL/day ) or a history of dialysis 28 days before surgery,
  • A history of gastrointestinal bleeding or bleeding diathesis 6 weeks before surgery, therapeutic dose of anticoagulation therapy (except subcutaneous heparin prophylactic dose),
  • Angiotensin converting enzymes inhibitor or antihypertensive combination with furosemide,
  • A history of opioid addiction or opioid tolerance
  • Allergy to study drugs,
  • Noncooperative patients for pain assessments

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

40 participants in 2 patient groups

ibuprofen and morphine
Experimental group
Description:
iv ibuprofen 800 mg infusion at 30 min before skin incision closed and per 6 hours during postoperative period; iv morphine with patient controlled analgesia (1 mg demand bolus dose, 20 min lockout time)
Treatment:
Drug: ibuprofen
paracetamol and morphine
Active Comparator group
Description:
iv paracetamol 1 gram infusion at 30 min before skin incision closed and per 6 hours during postoperative period; iv morphine with patient controlled analgesia (1 mg demand bolus dose, 20 min lockout time)
Treatment:
Drug: paracetamol

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems