Comparisons of the Impact of Duloxetine Versus Imipramine on Therapeutic Efficacy, Psychological Distress, Sexual Function, Urethral and Bladder Wall Structure and Blood Flow in Women With Stress Urinary Incontinence: a Randomized Controlled Study

Far Eastern Memorial Hospital

Status and phase: Withdrawn; Phase 3

Conditions: Stress Urinary Incontinence

Treatments: Drug: Duloxetine; Drug: Imipramine

Study type: Interventional

Funder types: Other

Identifiers

NCT04412876

109017-F

Details and patient eligibility

About

To assess the impact of Duloxetine and Imipramine on therapeutic efficacy, psychological distress, sexual function, bladder wall structure and blood flow in women

Full description

To assess the impact of Duloxetine and Imipramine on therapeutic efficacy, psychological distress, sexual function, bladder wall structure and blood flow in women

Sex: Female

Ages: 25+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Stress urinary incontinence

Exclusion criteria

1. Take monoamine oxidase
2. Myocardial infarction critical,cardiovascular insufficiency (such as room blocking, arrhythmia, blood-soaked heart failure, myocardial infarction, stroke and excessive heartbeat).
3. Allergy to duloxetine or imipramine
4. Uncontrolled angular glaucoma patients
5. Pregnant women

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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0 participants in 2 patient groups

Duloxetine

Experimental group

Description:

Receive Duloxetine 30 mg treatment per day

Treatment:

Drug: Duloxetine

Imipramine

Active Comparator group

Description:

Receive Imipramine 25 mg treatment per day

Treatment:

Drug: Imipramine