Comparitive Study of Two Misoprostol Regimen in Early Pregnancy Termination

Hormozgan University of Medical Sciences

Status: Completed

Conditions: Termination

Treatments: Drug: Misoprostol 800 micrograms; Drug: Misoprostol 400 micrograms

Study type: Interventional

Funder types: Other

Identifiers

NCT01508143

Misoprostol in termination

Details and patient eligibility

About

The aim of this study is to compare two misoprostol regimen in pregnancy termination.

Full description

Studies on determining the optimal dosage for misoprostol in pregnancy termination are continuing and still there is no evidence for ideal misoprostol regimen for pregnancy termination. The aim of this study is to compare two misoprostol regimen in pregnancy termination.

Enrollment: 41 patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• All women who were candidates for early pregnancy termination because of fetal death or other medical conditions
• Before 14th week of gestation calculated according LMP or first trimester sonography

Exclusion criteria

• Chorioamnionitis
• Hypersensitivity to prosstaglandins
• Past medical history of cardiovascular, kidney or liver or lung diseases
• Positive history for uterus pathologies
• suspicious to extra-uterus pregnancy
• sign and symptoms of uterus infection
• Molar pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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41 participants in 2 patient groups

400 microgram misoprostol

Experimental group

Description:

400 micrograms misoprostol each 6 hours for 8 dose

Treatment:

Drug: Misoprostol 400 micrograms

800 micrograms misoprostol

Active Comparator group

Description:

800 micrograms misoprostol each 12 hours for 4 dose

Treatment:

Drug: Misoprostol 800 micrograms