COMpassion for Psychiatric Disorders And Self-Stigma (COMPASS)

University Hospital, Strasbourg, France

Status: Enrolling

Conditions: Autism Spectrum Disorder; Borderline Personality Disorder; Schizophrenia; Bipolar Disorder; Depression

Treatments: Behavioral: Compassion Focused Therapy; Behavioral: Ending Self Stigma

Study type: Interventional

Funder types: Other

Identifiers

NCT05698589

8566

Details and patient eligibility

About

People with mental disorders face frequent stigmatizing attitudes and behaviors from others . In response to this, they tend to isolate themselves, with the risk of impeding care and the process of recovery and integration into society . Stigmatization can also be assimilated by patients themselves - i.e. self-stigma. Self-stigma is involved in diminished coping skills that lead to social avoidance and difficulties in adhering to care . Reducing self-stigma and its emotional corollary, shame, is thus crucial to attenuate the disability associated with mental illness. Shame is inherent to self-stigma and leads to difficulties in adhering to care as well as greater severity of clinical presentations . Compassion Focused Therapy (CFT) is a third wave cognitive behavioral therapy that targets shame reduction and hostile self-to-self relationship and allows for symptom improvement while increasing self-compassion, a major resilience factor . Although shame is a prominent part of the concept of self-stigma, the efficacy of CFT has never been evaluated in individuals with high levels of self-stigma.

In this study, the investigators will evaluate the efficacy and acceptability of a group based CFT program on decreasing self-stigma, compared to treatment as usual (TAU) and a psychoeducation program whose efficacy has been assessed in a previous trial.

Enrollment: 336 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

1. Patient ≥18 years of age

2. Patient informed of the results of the preliminary medical examination

3. Patient affiliated to a social health insurance plan (beneficiary or beneficiary's family)

4. Patient with one or several diagnoses of chronic psychiatric disorder (schizophrenia, schizoaffective disorder, bipolar disorder, recurrent major depression, borderline personality disorder) or a neurodevelopmental disorder (autism spectrum disorder) treated as an outpatient or in a day hospital

5. CGI-Severity score<6 assessed by the psychiatrist (Berk et al., 2008) ISMI score indicating moderate to high self-stigma (>2.5; Lysaker et al., 2007)

   Exclusion criteria:

6. Patient in an exclusion period determined by a previous or ongoing study

7. Patient participating in an interventional study involving psychotherapy or an experimental drug

8. Patient in acute episode of their disorder according to the CGI Severity score

9. Patient in a medical emergency or immediate life-threatening situation

10. Patients with an intellectual disability (IQ<70) estimated via the fNART (Mackinnon & Mulligan, 2005)

11. Legal issues: care under constraint or patient deprived of freedom because of a judicial measure 13. Patient who does not speak and read French sufficiently

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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336 participants in 3 patient groups

Compassion Focused Therapy

Experimental group

Treatment:

Behavioral: Compassion Focused Therapy

Ending Self Stigma

Active Comparator group

Treatment:

Behavioral: Ending Self Stigma

Treatment As Usual

No Intervention group