Compassionate Use Study of Pergolide in Patients With Parkinson's Disease

Bausch Health

Status

Conditions: Parkinson Disease

Treatments: Drug: Pergolide

Study type: Expanded Access

Funder types: Industry

Identifiers

NCT00624741

PRG-001

Details and patient eligibility

About

This compassionate use study is designed to monitor safety in patients who have been doing well on pergolide therapy, wish to continue treatment, and have not been able to tolerate alternative treatments.

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosed with Parkinson's disease and treated successfully with pergolide in the recent past
• Attempt to taper off pergolide was unsuccessful and patient was unable to change to other forms of therapy for Parkinson's disease
• No evidence of cardiovalvular disease by echocardiogram conducted within 60 days prior

Exclusion criteria

• History or current diagnosis of cardiac valvulopathy
• Inability to undergo echocardiograms every 6 months while receiving pergolide
• Hypersensitivity to pergolide or other ergot derivatives