Compensatory Brain Mechanisms for Amygdala-associated Cognitive Dysfunction: Potential Role of the Cortical Mirror Neuron System

University of Electronic Science and Technology of China

Status: Unknown

Conditions: Healthy

Treatments: Behavioral: screen high and low triat subjects

Study type: Observational

Funder types: Other

Identifiers

NCT03723733

UESTC-neuSCAN-28

Details and patient eligibility

About

Identify if the mirror neuron system, or other networks, can compensate for amygdala dysfunction, using behavior and structural/functional MRI.

Full description

In the present study, investigators aim to investigate amygdala dysfunction & potential compensation in individuals with high and low traits (e.g. Autism, Anxiety, Depression traits, Alexithymia), high and low stress or protective factors in the environment (social network, early life stress) and different molecular genetic make-up. On the neural level, functional and structural connectivity as well as task-related BOLD activation will be assessed.

Enrollment: 350 estimated patients

Sex: All

Ages: 17 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy subjects

Exclusion criteria

• history of head injury
• claustrophobia;
• medical or psychiatric illness
• female subjects were pregnant or taking oral contraceptives.
• taking any form of medication and drunk any caffeine-containing beverages on the day of the experiment.