Compensatory Training to Support Brain Healthy Lifestyle Changes in Those at Risk for Alzheimer's Disease

Mayo Clinic

Status: Completed

Conditions: Alzheimer Disease; Pre Senile Dementia; Cognitive Symptom

Treatments: Behavioral: Cognitive rehabilitation and health behavior change intervention; Behavioral: Self-implementation

Study type: Interventional

Funder types: Other

Identifiers

NCT04118985

19-006676

Details and patient eligibility

About

The Researchers are trying to better understand if behavioral interventions can help improve memory compensation and engagement in healthy lifestyle behaviors in those with memory concerns but normal mental status exam.

Enrollment: 21 patients

Sex: All

Ages: 50+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 50 or older
• A positive complaint or concern in response to two questions ('Do you feel like your memory or other aspects of thinking are becoming worse?' and 'Does this worry you?')
• Normal cognitive performance on the Montreal Cognitive Assessment (adjusted for age and education)
• Self-reported independent function in daily life as measure by the Lawson IADL scale (IADL=8)
• English speaking
• Approval letter from a physician (due to the exercise component)

Exclusion criteria

• Known neurological disorder with potential cognitive symptoms (a diagnosis of Parkinson's disease, epilepsy, a history of significant TBI, etc.)
• Uncontrolled moderate or severe depression (e.g., CES-D > 21).

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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21 participants in 2 patient groups

Self-implementation

Active Comparator group

Description:

Individuals randomized to this group will be given all the materials about cognitive compensations techniques and brain health behavior guidelines and encouraged to implement those on their own.

Treatment:

Behavioral: Self-implementation

Health-behavior intervention

Experimental group

Description:

Individuals randomized to this group will attend 10 weekly classes designed to provide information about cognitive compensation techniques and brain health behaviors as well as interventional support to implement those recommendations with homework and follow-up classes.

Treatment:

Behavioral: Cognitive rehabilitation and health behavior change intervention