Competitive Accuracy of Radiological Imaging Compared to Liver Biopsy in Patients With Liver Fibrosis

Vilnius University

Status: Completed

Conditions: Liver Fibroses; Liver Cirrhosis

Treatments: Diagnostic Test: Liver elastography (2D-SWE); Diagnostic Test: Liver scintigraphy with 99mTc-mebrofenin

Study type: Observational

Funder types: Other

Identifiers

NCT05008263

158200-18/7-1053-552

Details and patient eligibility

About

The study "Competitive Accuracy of Radiological Imaging Compared to Liver Biopsy in Patients With Liver Fibrosis" is designed to test the accuracy of non-interventional radiological imaging and compare its results with the "gold standard" liver biopsy. This is prospective non-randomized single patient group study.

Enrollment: 72 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• chronic liver disease
• signed informed consent
• liver biopsy indicated by treating gastroenterologist/infectologist

Exclusion criteria

• non-corrected blood coagulation tests
• acute liver disease
• age below 18 years or above 80 years
• disagreement to participate in the study
• pregnancy

Trial design

72 participants in 1 patient group

Patients with viral chronic liver disease at primary diagnosis

Description:

Patients with primary diagnosis of viral hepatitis B and hepatitis C who was referred for liver biopsy. All patients underwent liver shear wave elastography and dynamic liver scintigraphy evaluating liver physical and functional changes shortly prior to liver biopsy procedure.

Treatment:

Diagnostic Test: Liver elastography (2D-SWE)

Diagnostic Test: Liver scintigraphy with 99mTc-mebrofenin