Complement Activation During Hemodialysis in Atypical Hemolytic Uraemic Syndrome as Underlying Kidney Disease

Ghent University Hospital (UZ)

Status: Completed

Conditions: Atypical Hemolytic Uraemic Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT00930423

2009/270

Details and patient eligibility

About

Atypical hemolytic uraemic syndrome is caused by defects in the regulating factors in the alternative pathway of the complement system. Triggering can cause an uncontrolled complement activation with endothelial damage and thrombotic micro-angiopathy, especially in the kidneys. This can result in endstage renal failure. Complement activation during hemodialysis has been described as a result of contact between blood and the dialysis membrane. Our hypothesis is that patients with atypical hemolytic uraemic syndrome have a stronger complement activation during hemodialysis than patients with another underlying kidney disease. This could be a reason to treat patients with endstage renal failure due to atypical hemolytic uraemic syndrome preferentially with peritoneal dialysis instead of hemodialysis.

Enrollment: 25 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• cases: endstage renal failure due to atypical hemolytic uraemic syndrome treated with hemodialysis.
• controls: endstage renal failure due to a non complement consuming nephropathy treated with hemodialysis.

Trial design

25 participants in 2 patient groups

cases

Description:

patients with endstage renal failure due to atypical uraemic syndrome treated with hemodialysis.

controls

Description:

patiënts with endstage renal failure due to a non complement consuming nephropathy treated with hemodialysis.