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The purpose of this study is to cast light on the highly complex etiology and cellular landscape of hip osteoarthritis by utilising single-cell and spatial transcriptomics.
Full description
The specific objectives of this project are:
The project includes a Rheumatoid sub-study where the main objective is to compare arthritic tissue and peripheral blood constituents between OA and rheumatoid arthritis patients to explore the differences in the disease mechanisms.
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Inclusion and exclusion criteria
Inclusion Criteria for the main (OA) study:
Cases: Adult patients with osteoarthritis in the hip joint and who are going through an elective total hip arthroplasty.
Controls: Non-arthritis adult patients who are going through a trauma-based emergency total hip arthroplasty.
Inclusion Criteria for the Rheumatoid sub-study:
Adult patients with rheumatoid arthritis in the hip joint and who are going through an elective total hip arthroplasty.
Exclusion Criteria:
For the Rheumatoid sub-study, the exclusion criteria are the same as above except for the RA.
65 participants in 3 patient groups
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Central trial contact
Lea Mikkola, PhD
Data sourced from clinicaltrials.gov
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