Complications and Antiplatelet and Anticoagulant Therapy in Vascular Surgery.

Petrovsky National Research Centre of Surgery

Status: Active, not recruiting

Conditions: Cerebral Hypoxia During and/or Resulting From A Procedure; Thrombosis; Bleeding

Treatments: Drug: Ticagrelor; Drug: Clopidogrel; Drug: Dabigatran; Drug: Aspirin + rivaroxaban; Drug: Warfarin; Drug: Clopidogrel + Rivaroxaban; Drug: Aspirin + Apixaban; Drug: Aspirin; Drug: Rivaroxaban; Drug: aspirin + clopidogrel; Drug: Aspirin + Ticagrelor; Drug: Apixaban; Drug: Clopidogrel + Apixaban

Study type: Observational

Funder types: Other

Identifiers

NCT07358416

ComplVasc2025Retro

Details and patient eligibility

About

The goal of this retrospective clinical trial is to find out association antiplatelet and anticoagulant therapy with perioperative complications in non-cardiac vascular surgery in patients . The main questions it aims to answer are:

Does the use of antiplatelet agents and anticoagulants affect the development of complications in the perioperative period during operations on the main arteries? Does discontinuing antiplatelet and anticoagulant medications affect the development of perioperative complications in major artery surgeries?? Researchers will compare with patients who didn't use antiplatelets and anticoagulant drugs to see ift he incidence of complications comparable?

This is a retrospective study based on the analysis of medical records (case histories).

Enrollment: 500 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who received surgical treatment on the main arteries.

Exclusion criteria

• Patients who received surgical treatment on the main veins.

Trial design

500 participants in 3 patient groups

Control

Description:

Patients who did not take antiplatelet agents and anticoagulants

Antiplatelet and anticoagulants

Description:

Patients who use antiplatelet agents and anticoagulants until the operation day

Treatment:

Drug: Clopidogrel + Apixaban

Drug: Apixaban

Drug: Aspirin + Ticagrelor

Drug: aspirin + clopidogrel

Drug: Rivaroxaban

Drug: Aspirin

Drug: Aspirin + Apixaban

Drug: Clopidogrel + Rivaroxaban

Drug: Warfarin

Drug: Aspirin + rivaroxaban

Drug: Dabigatran

Drug: Clopidogrel

Drug: Ticagrelor

Discontinuation of antiplatelet and anticoagulants

Description:

Patients who discontinuate antiplatelet agents and anticoagulants until the operation day