Complications and the Influence of COVID-19 on Myocardial Function and Exercise Capacity

Polish Mother Memorial Hospital Research Institute

Status

Active, not recruiting

Conditions

Covid19

Heart Failure

Treatments

Diagnostic Test: Diagnostic tests

Study type

Observational

Funder types

Other

Identifiers

NCT04828629

PMMHRI-BCO.75/2020

Details and patient eligibility

About

The subject of the study is the impact of COVID-19 on the indicators of myocardial efficiency and exercise capacity. As a result of the observed dependencies, it will be possible to start an appropriate diagnostic procedure early, select personalized treatment and develop a model of cardiological care for people with a history of SARS-CoV-2 infection and improve the quality and extend their life.

Full description

About 100 adult patients hospitalized in the Department of Cardiology and Congenital Heart Diseases of Adults who had recovered from COVID-19 will be included in the study. Selected prognostic factors will be analyzed, among others: demographic data of the patient, physical examination, symptoms, co-morbidities, results of selected laboratory tests, lung imaging (X-ray or computed tomography) selected electrocardiographic and echocardiographic data, patient's cooperation with the doctor, treatment applied, parameters in the spiroergometric study, body mass analysis. One year after inclusion in the study, a control hospitalization will be performed. The same factors will be analyzed.

Enrollment

100 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age equal to or older than 18 years
infection with the SARS-CoV-2 in past medical history
current hospitalization

Exclusion criteria

severe hypertension;
unstable angina;
acute pulmonary embolism;
decompensated heart failure;
recent myocardial infarction;
unstable heart rhythm disturbances;
acute myocarditis or pericarditis;
active endocarditis;
advanced atrioventricular block;
diagnosis of cardiomyopathy (hypertrophic, dilated, restrictive, peripartum, arrhythmogenic)
lysosomal storage disorders
severe hyper- and hypothyroidism
pregnancy and lactation
chronic kidney disease (IV, V stadium according to NKF) and dialysis treatment
documented neoplastic process
the patient's inability to cooperate and/or provide informed consent to participate in a research
alcohol and drug abuse
active autoimmune disease
treatment using immunosuppressants, cytostatic drugs, glucocorticosteroids, or antiretroviral drugs
a history of bone marrow transplant or other organ transplant, treatment with blood products within the last 6 months
active systemic infection
HBV, HCV or HIV carrier or positive for HbS antigen or antibodies to HCV
surgery or serious injury within the last month
patients who did not express their informed consent to participate in the study