Complications of High Frequency Jet Ventilation

Free University of Brussels (ULB)

Status: Enrolling

Conditions: High-Frequency Jet Ventilation; Bronchoscopy

Treatments: Procedure: High frequency jet ventilation

Study type: Observational

Funder types: Other

Identifiers

NCT06285994

SRB2024016

Details and patient eligibility

About

High frequency jet ventilation (HFJV) has been introduced in 1967 as technique allowing ventilation with simultaneous access to the airway for bronchoscopy. Continuous improvement in the technique has led to a large use during interventional bronchoscopy, especially in large centers. However, complications occuring during the use of HFJV are poorly known. In this retrospective cohort study, the charts of all patients who had a bronchoscopy with the use of HFJV between 2019 and 2023 in our hospital will be analyzed. Primary outcome will the description of all complications during HFJV. Complications are defined as:

• Hypoxia: SpO2 < 90% for 1 min
• Severe hypoxia: SpO2 < 85% for 1 min
• Hemodynamic instability, defined as Arterial pressure < 90/60
• Cardiac arrhythmia
• Laryngospasm or bronchospasm
• Barotrauma or volutrauma
• Need for ICU admission

A model predicting the risk for developing any complication will be developped using 2 mathematical methods:

• a multivariate analysis
• a data mining approach

For both approaches, the following variables will be included in the model:

• Age

• Gender

• Weight

• Height

• BMI

• Smoking

• Alcohol consumption

• Consumption of Other drugs

• ASA class

• Obstructive pulmonary disease

• Restrictive lung disease

• COPD status (1, 2, 3, 4)

• Interstitial lung disease

• Lung tumor

  • Trachea location
  • Carina location
  • Bronchial location

• Pulmonary or tracheal stenosis

• Presence of stridor

• Severe stenosis (< 6 mm)

• Baseline SpO2 (pre-intervention)

• Pre-intervention oxygen requirement Procedure

• Duration (min)

• Stent placement

• Dilation

• Laser treatment

• Length of hospital stay Lung function tests

• FEV1 (forced expiratory volume)

• VC (Vital Capacity)

• FEV1/VC (Tiffeneau ratio)

• CPT (total lung capacity)

• DLCO (carbon monoxide diffusion)

Enrollment: 1,200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients who underwent a bronchoscopy with the use of high frequency jet ventilation between January 1st, 2019 and December 31st, 2023 at Erasme University Hospital, Brussels

Exclusion criteria

• Incomplete medical chart
• Patient who expressed their opposition to the use of their medical data

Trial design

1,200 participants in 1 patient group

HFJV

Description:

All patients who underwent bronchoscopy with the use of high frequency jet ventilation between January 1st 2019 and december 31st 2023.

Treatment:

Procedure: High frequency jet ventilation