Composite Ratios Boost CRP's Power in Monitoring Ulcerative Colitis.

Benha University

Status: Completed

Conditions: Ulcerative Colitis

Treatments: Diagnostic Test: CRP to Albumin Ratio; Diagnostic Test: C-Reactive Protein measuring CRP

Study type: Observational

Funder types: Other

Identifiers

NCT07261579

E/C. S/N. R14/2025

Details and patient eligibility

About

Inflammatory Bowel Disease (IBD) is a chronic, recurrent condition marked by disturbed levels of various hematological inflammatory cells and a deregulated immune environment. While C-reactive protein (CRP) is a key acute-phase reactant, its high levels can persist even after inflammation subsides. Other simple, cost-effective ratios, such as the Neutrophil-to-Lymphocyte Ratio (NLR), the Platelet-to-Lymphocyte Ratio (PLR), and Albumin-related ratios, also serve as promising, reproducible markers of systemic inflammation reflecting both immune status and nutrition. This study's objective is to evaluate the diagnostic performance of these various hematological inflammatory cellular components and CRP-related ratios (like the CAR) as predictors for Ulcerative Colitis (UC) disease severity, using colonoscopic and microscopic findings as the gold standard for comparison.

Enrollment: 80 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who fulfilled the diagnostic criteria for UC;
• Patients were free of exclusion criteria;
• Patients who signed the written consent were enrolled in the study

Exclusion criteria

• Patients who was Previously diagnosed with IBD or IBS;
• Patients with recurrence of manifestations after surgical resection;
• Patients who refused to sign the participation consent.

Trial design

80 participants in 1 patient group

Ulcerative Colitis Patients

Description:

Patients exhibiting clinical signs suggestive of IBD were assessed for UC diagnostic criteria, and the study inclusion and exclusion standards.

Treatment:

Diagnostic Test: C-Reactive Protein measuring CRP

Diagnostic Test: CRP to Albumin Ratio