Comprehensive Functional Assessments for NOCAD

Fudan University

Status: Completed

Conditions: Coronary Artery Disease; Myocardial Ischemia; Coronary Microvascular Dysfunction

Treatments: Device: coronary physiological indices

Study type: Observational

Funder types: Other

Identifiers

NCT06175572

ZS20231202

Details and patient eligibility

About

To validate and investigate the efficacy of comprehensive functional assessments for the diagnostic and prognostic value in NOCAD.

Enrollment: 1,000 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. visual evaluation of epicardial coronary artery diameter stenosis (DS%) ≤ 50%;
2. CZT-SPECT was successfully conducted within three days of CAG

Exclusion criteria

1. had flow-limiting epicardial stenosis (DS% >50%) or angiography-derived FFR (Angio-FFR) ≤ 0.8;
2. severe valvular heart disease;
3. chronic heart failure and/or left ventricular ejection fraction (LVEF) of < 50%;
4. cardiomyopathy and myocarditis;
5. severe renal or hepatic insufficiency;
6. failure in detecting SPECT;
7. failure in computing Angio-IMR, and -FFR.

Trial design

1,000 participants in 4 patient groups

NCF cohort

Description:

Normanl coronary-flow patients referred to coronary angiography and undergo assessment with single photon emission computed tomography imaging (SPECT).

Treatment:

Device: coronary physiological indices

CSF cohort

Description:

Coronary slow-flow patients referred to coronary angiography and undergo assessment with single photon emission computed tomography imaging (SPECT).

Treatment:

Device: coronary physiological indices

ANOCA cohort

Description:

Angina with nonobstructive coronary artery patients referred to coronary angiography and undergo assessment with single photon emission computed tomography imaging (SPECT).

Treatment:

Device: coronary physiological indices

INOCA cohort

Description:

Ischemia with nonobstructive coronary artery patients referred to coronary angiography and undergo assessment with single photon emission computed tomography imaging (SPECT).

Treatment:

Device: coronary physiological indices