Comprehensive Strategy to Decolonize Methicillin-resistant Staphylococcus Aureus (MRSA) in the Outpatient Setting

Joseph Kim

Status: Completed

Conditions: Methicillin-resistant Staphylococcus Aureus

Treatments: Behavioral: Education; Drug: pharmacological decolonization treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT01232231

E23134

Details and patient eligibility

About

The purpose of this study is to determine the effectiveness of topical and oral antibiotics in eliminating carriage of methicillin-resistant Staphylococcus aureus (MRSA) among those living in the community. We hypothesize that a greater proportion of those who receive intervention will eliminate MRSA carriage compared to those who do not receive any intervention.

Enrollment: 15 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Prior MRSA infection (i.e index case)
• Identified as being colonized with MRSA on initial screen

Exclusion criteria

• Are pregnant or breastfeeding.
• Have indwelling catheters.
• Received prior decolonization treatment within last 6 months of enrollment.
• Have allergy to study medication.
• Are colonized with MRSA strain resistant to study medication.
• Have active infection requiring systemic antimicrobials.
• Are household contacts to index case.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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15 participants in 2 patient groups

decolonization treatment

Active Comparator group

Description:

topical antiseptic, intranasal antimicrobial, and oral antimicrobial that have activity against MRSA in addition to education regarding personal hygiene and environmental cleaning

Treatment:

Drug: pharmacological decolonization treatment

education

Other group

Description:

No decolonization treatment in addition to education regarding personal hygiene and environmental cleaning

Treatment:

Behavioral: Education