Computed Tomography-Guided Stereotactic Adaptive Radiotherapy (CT-STAR) for the Treatment of Central and Ultra-Central Early-Stage Non-Small Cell Lung Cancer

The Washington University

Status: Enrolling

Conditions: Non-small Cell Lung Cancer; Early Stage Non-small Cell Lung Cancer

Treatments: Device: ETHOS; Radiation: Computed tomography-guided stereotactic adaptive radiotherapy

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT05785845

202302003

Details and patient eligibility

About

This study will evaluate the impact of CT-guided adaptive stereotactic radiotherapy (CT-STAR) to central and ultra-central early-stage non-small cell lung cancers on grade 3 or greater toxicity. Online adaptive radiation therapy was until recently only done clinically on an integrated MRI-guided system, but recently, Varian Medical Systems has created a CT-guided radiotherapy machine capable of online adaptive radiotherapy (ETHOS). The vast majority of stereotactic body radiotherapy (SBRT) for early-stage lung cancers is performed on a CT-guided machine rather than an MRI-guided machine, necessitating the evaluation of adaptive radiotherapy using ETHOS in this population. Historically, the non-adaptive, stereotactic treatment of central and ultra-central thoracic disease has been associated with unacceptable rates of grade 3+ toxicity. This has resulted in widespread adoption of a hypofractionated, less ablative 8-15 day treatment courses, with a baseline, one-year grade 3+ toxicity rate of 20%. Use of CT-STAR with daily, CT-guided plan adaptation to carefully spare adjacent organs-at-risk (OAR) in this setting may enable safe delivery of a shorter (5 fraction) and more ablative radiotherapy course.

Enrollment: 17 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Histologically or radiographically diagnosed stage I-IIA (AJCC, 8th ed.) non-small cell lung cancer or mediastinal recurrent non-small cell lung cancer with plans to be treated with definitive intent SBRT alone.

  • Clinical AJCC stage I defined as stage 1A1 (T1a1N0M0, T1a tumor less than or equal to 1 cm), stage 1A2 (T1bN0M0, T1b tumor between 1 and 2 cm), and stage 1A3 (T1cN0M0, T1c tumor between 2 and 3 cm).
  • Clinical AJCC stage IB defined as T2aN0M0, T2a tumor between 3 and 4 cm.
  • Clinical AJCC stage IIA defined as T2bN0M0, T2b tumor between 4 and 5 cm.

• Lesions must be defined as central or ultra-central according to the Hilus-trial13 criteria:

  • Central lesions are defined as lesions 1 cm or less from the trachea, carina, main bronchi, bronchus intermedius, or lobar bronchi.
  • Ultra-central lesions are defined as lesions touching the trachea, carina, main bronchi, bronchus intermedius, or lobar bronchi. Lesions that touch the esophagus, great vessels, or heart may also be included as ultra-central.

• Tumor coverage is deemed adequate in simulation treatment planning as determined by the treating and study physicians. Specifically, the dose to 98% of the GTV must be greater than 45 Gy.

  • Note: patients with inadequate tumor coverage at simulation will be considered screen-failures and treated off-protocol as per institutional standard-of-care. *In a in silico analysis of these patients, only 1/6 patients screen-failed based on this inclusion criteria.

• Patients should be able to hold their breath for 10 seconds.

• Inoperable disease or patient has refused/declined surgery.

• Deemed medically fit for SBRT by the treating physician.

• At least 18 years of age.

• Zubrod Performance Status 0-2 within 30 days prior to registration.

• Appropriate stage for protocol entry based upon the following minimum diagnostic workup.

  • History/physical examination within 30 days prior to registration.
  • FDG-PET/CT scan and/or CT chest (with or without contrast) for staging within 60 days prior to registration.

• Adequate bone marrow and hemostasis function determined no more than 30 days prior to registration, defined as follows:

  • Platelets ≥ 150,000 cells/mm3
  • Hemoglobin ≥ 8 g/dl

• Able to understand and willing to sign an IRB approved written informed consent.

Exclusion criteria

• Lesions appearing to extend through the bronchial or great vessel walls on CT imaging.

• Prior or concurrent malignancies, unless the natural history of the prior or concurrent malignancy does not have the potential to interfere with the interpretation of the results of the study.

• Patients with a pre-existing, active diagnosis of metastatic cancer.

• Severe, active comorbidity, defined as follows:

  • Unstable angina, history of myocardial infarction and/or congestive heart failure requiring hospitalization within the last 6 months;
  • Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration;
  • Chronic Obstructive Pulmonary Disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration;
  • Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects; note, however, that laboratory tests for liver function and coagulation parameters are not required for entry into this protocol.

• Past history of radiotherapy within the projected treatment field of any of the disease sites to be treated by CT-guided SBRT.

• Pregnant and/or breastfeeding. Patient must have a negative pregnancy test within 14 days of the start of SBRT.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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17 participants in 1 patient group

Computed Tomography-Guided Stereotactic Adaptive Radiotherapy (CT-STAR)

Experimental group

Description:

In this study, consenting and eligible patients will receive a prescription dose of 55 Gy in 5 fractions (when possible) delivered on consecutive business days with adaptation based on daily anatomic changes as per clinical standard of care.

Treatment:

Radiation: Computed tomography-guided stereotactic adaptive radiotherapy

Device: ETHOS