Computed Tomography Versus Exercise Testing in Suspected Coronary Artery Disease (CRESCENT)

Erasmus University

Status: Terminated

Conditions: Chest Pain; Angina Pectoris

Treatments: Other: Cardiac CT; Other: Standard care

Study type: Interventional

Funder types: Other

Identifiers

NCT01393028

CRESCENT-11

Details and patient eligibility

About

Direct non-invasive coronary imaging by computed tomography (CT) has the potential to improve the workup of patients with stable chest pain complaints. The objective of the study is to compare in a randomized fashion the effectiveness and efficiency of a CT angiographic driven workup of suspected coronary artery disease in comparison to the standard workup using stress testing.

Enrollment: 350 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Men and women aged >18 years.
• Stable symptoms of chest pain or dyspnea potentially caused by obstructive CAD.

Exclusion criteria

• A history of surgical or percutaneous coronary revascularization
• Non-revascularized angiographic obstructive coronary artery disease (>50% diameter reduction).
• Normal invasive coronary angiography or stress imaging less than 1 years ago.
• Inability or unwillingness to provide informed consent.

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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350 participants in 2 patient groups

Cardiac CT

Experimental group

Description:

Cardiac CT (CT calcium and/or CT angiography), followed by stress testing, invasive angiography or neither depending on the CT scan result

Treatment:

Other: Cardiac CT

Standard care

Other group

Description:

Standard diagnostic management, including stress testing and/or invasive angiography

Treatment:

Other: Standard care