Computer-based Dosage Calculation for Antibiotics

University Hospital Tuebingen

Status: Withdrawn

Conditions: Anti-Infective Agent Toxicity; Acute Kidney Insufficiency

Treatments: Drug: Meropenem; Drug: Piperacillin/tazobactam

Study type: Observational

Funder types: Other

Identifiers

NCT03036826

CADDy

Details and patient eligibility

About

Adequate dosing of antiinfective therapy in critically ill patients with impaired or lost renal function or continuous renal replacement therapy is nearly impossible without measuring the drug concentration in blood samples. In many hospitals that is still not an option. The investigators aim to show, that computer based calculation can avoid over- or under-dosing.

Full description

Adequate dosing of antiinfective therapy in critically ill patients is most important to improve outcome. Patients with impaired or lost renal function or continuous renal replacement therapy are hard to calculate using drug information sheets or "lists" with recommendations. It is nearly impossible to avoid drug levels that are much to low or much to high without measuring the concentration in blood samples. Since that possibility is still not available in every clinic we aim to show, how a computer based calculation can help to find the adequate dosing.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients requiring antiinfective therapy
• patients with impaired renal function or requiring continuous renal replacement therapy

Exclusion criteria

• plasmapheresis or liver replacement therapy
• renal replacement therapy with integrated CytoSorb®-Membrane
• extracorporal live support

Trial design

0 participants in 2 patient groups

Piperacillin/Tazobactam

Description:

Group of patients receiving Piperacillin/Tazobactam as antiinfective therapy

Treatment:

Drug: Piperacillin/tazobactam

Meropenem

Description:

Group of patients receiving Meropenem as antiinfective therapy

Treatment:

Drug: Meropenem