Computerized Cognitive Training in Epilepsy

NYU Langone Health

Status: Withdrawn

Conditions: Epilepsy

Treatments: Behavioral: Memory Matrix Exercise; Behavioral: Pair-Match (Across-Modality) Exercise; Behavioral: Story Recall Exercise; Behavioral: Lost in Migration Exercise; Behavioral: Temporal Sequence Reconstruction Exercise; Behavioral: Monster Garden Exercise; Behavioral: Playing Koi Exercise; Behavioral: Sample-Match (Within Modality) Exercise; Behavioral: Spatial Match Exercise; Behavioral: Token Task Exercise; Behavioral: Memory Match Exercise; Behavioral: Familiar Faces Exercises; Behavioral: Triad-FiguresExercise

Study type: Interventional

Funder types: Other

Identifiers

NCT02726191

15-00398

Details and patient eligibility

About

The purpose of this randomized uncontrolled single-site trial is to evaluate the efficacy of two novel computerized cognitive enhancing software packages for improving cognitive and behavioral outcomes in patients with epilepsy.

Full description

The proposed investigation will be the first to pit two software packages against each other to evaluate the relative efficacy and feasibility of their use among patients with epilepsy. Pharmacotherapy fails to control seizures in approximately 30% of patients. Use of non-pharmacologic interventions, such as cognitive rehabilitation, has shown some benefit for improving cognitive functions and reducing mood symptoms. Each of the computer exercises employ a set of stimuli that are generalizable and mimic real-world experiences.

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Documented diagnosis of epilepsy based on medical records. The records will be reviewed by the PI and the approved study personnel to confirm that a diagnosis of epilepsy has been made.
• Must own a computer or have access to the internet.

Exclusion criteria

• Full Scale IQ < 80, as assessed by the WASI-II.
• History of chronic progressive neurologic or neurodegenerative illnesses (e.g., Parkinson's disease, multiple sclerosis, dementia, primary or metastatic malignancy). Patients with headache or migraine are not excluded.
• History of Axis I psychiatric illness with psychotic features. (e.g., schizophrenia). Patients with depression or anxiety (treated or untreated) without psychotic features are not excluded.
• Visual or auditory impairment, which precludes participation in part, or all of the testing.
• English as a first language will not be required, but participants must have either received some of their schooling in English or used English in their work for >10 years.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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0 participants in 2 patient groups

Posit Science

Experimental group

Treatment:

Behavioral: Token Task Exercise

Behavioral: Temporal Sequence Reconstruction Exercise

Behavioral: Pair-Match (Across-Modality) Exercise

Behavioral: Story Recall Exercise

Behavioral: Triad-FiguresExercise

Behavioral: Sample-Match (Within Modality) Exercise

Behavioral: Spatial Match Exercise

Lumosity

Experimental group

Treatment:

Behavioral: Lost in Migration Exercise

Behavioral: Monster Garden Exercise

Behavioral: Memory Matrix Exercise

Behavioral: Playing Koi Exercise

Behavioral: Memory Match Exercise

Behavioral: Familiar Faces Exercises