Computerized Olfactory Test - Alzheimer Disease Mild Stage

J

Jewish General Hospital

Status

Completed

Conditions

Olfaction Disorders
Alzheimer Disease

Treatments

Diagnostic Test: Olfactory test

Study type

Interventional

Funder types

Other

Identifiers

NCT03698760
2019-1509

Details and patient eligibility

About

This study evaluates the effectiveness of the smell tests that are used in early diagnosis of mild dementia.

Full description

For twenty years research has shown a strong link between olfactory disorders and Alzheimer's disease. The focus is on the very early alteration of the olfaction which acts as a harbinger of the disease since it is detectable in its asymptomatic phase. In addition, olfactory involvement is a precursor to the transformation of mild cognitive impairment into MA. Indeed the anatomical structures the first lesions are located in the transentorhinal region of the temporal lobe and entorhinal phase, before progressing towards the limbic system, which will mark the clinical appearance of the first signs of AD. In literature, it has been shown that there was no olfactory test that is recognized as a gold standard in the scientific community due to a lack of homogeneity of the tools used, their availability and their validity depending on the culture. Moreover, of all the tests currently available, none are specific to neurodegenerative diseases. Very recent studies show that there is also a strong preference for imaging tools or biomarkers in the detection of AD, but it appears that the olfactory disorders are well before these markers. It has been shown that an identification test is comparable in predictive accuracy to neuroimaging and cerebrospinal fluid sampling. This study will therefore focus on the calibration and validation of a computerized olfactory test for the diagnosis of Alzheimer's disease and based the recommendations of professionals so as to promote the effective use of this test in clinical practice.

Enrollment

82 patients

Sex

All

Ages

60+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Being 60 years old and over
  • The participants enrolled in the control group must have a score of the Mini-Mental State Exam test greater than or equal to 28.
  • The participants enrolled in the intervention group must have a diagnosis of Alzheimer's disease, and the score of the Mini-Mental State Exam test should be between 20 and 27

Exclusion criteria

  • Presenting an unstable, acute or current psychiatric or physical condition that is severe enough to prevent the participant from participating in the study, as determined by the investigator.
  • Having an uncorrected major visual or hearing impairment or anosmia (total olfaction loss).

Trial design

Primary purpose

Other

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

82 participants in 2 patient groups

Mild stage Alzheimer group
Experimental group
Description:
Participants with mild stage Alzheimer's disease
Treatment:
Diagnostic Test: Olfactory test
Control Group
Experimental group
Description:
Participants without cognitive disorders
Treatment:
Diagnostic Test: Olfactory test

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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