COMT Activity and Hypnotizability

Stanford University

Status: Unknown

Conditions: Genetic Predisposition; Pain, Postoperative

Treatments: Device: Giant magnetoresistive sensor (GMR)

Study type: Observational

Funder types: Other

Identifiers

NCT04624880

58341

Details and patient eligibility

About

Hypnosis is an effective pain management tool for surgery that can reduce opioid use up to 40%. COMT single nucleotide polymorphisms (SNPs) can predict pain sensitivity and opioid use perioperatively, and may also be associated with hypnotizability or response to hypnotic analgesia. Analyzing COMT haplotypes from DNA extracted from saliva or blood using a giant magnetoresistive (GMR) nanotechnology platform may be faster, less expensive, and at least as accurate as pyrosequencing. This study aims to validate a multi-SNP point-of-care (POC) GMR assay for the rapid genotyping of SNPs predictive of COMT activity, and test the feasibility of using COMT activity as a biomarker for hypnotizability and/or response to hypnotic analgesia.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Prior enrollment in one of 3 specific hypnosis trials
• Enrollment is by invitation only

Exclusion criteria

• Participants in the prior trials who declined to be contacted for future research.

Trial design

100 participants in 2 patient groups

Participants with HIP previously measured

Description:

This cohort of patients will have their genetics analyzed and compared to their HIP scores.

Treatment:

Device: Giant magnetoresistive sensor (GMR)

Participants without HIP measured

Description:

This cohort of patients from the control group of the knee replacement trial (who did not have their HIP measured) will have their genetics, pain, and opioid use analyzed, and compared to the genetics, pain, and opioid use of the hypnosis group from that trial.

Treatment:

Device: Giant magnetoresistive sensor (GMR)