Concentrated Platelet Rich Fibrin (C-PRF) as Adjunct to Non-surgical Periodontal Therapy

Krishnadevaraya College of Dental Sciences & Hospital

Status and phase: Completed; Phase 1

Conditions: Periodontal Pocket

Treatments: Biological: C-PRF

Study type: Interventional

Funder types: Other

Identifiers

NCT05958147

KCDSHEC/IP/2023/P7

Details and patient eligibility

About

The current study is a prospective randomised split mouth study to evaluate the effect of concentrated Platelet Rich Fibrin as an adjunct to the scaling and root planing

Full description

Twelve healthy individuals satisfying the inclusion and exclusion criteria were recruited for the study. A detailed, thorough medical and dental history was obtained and each patient was subjected to comprehensive clinical and radiological examination. All patients were informed about the nature of the study, procedure involved, potential benefits and risks associated with procedure and written informed consent were obtained from all patients.

All the patients underwent scaling and root planing. As it is split mouth study design the test site is treated with Concentrated platelet rich fibrin( C-PRF) and the contralateral site is not treated with C-PRF. Periodotal pack was placed and patient was recalled after 6 weeks for the follow up.

Enrollment: 48 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Patient age ranging from 18-45 years
2. Contralateral sites with probing depth 5mm-7mm associated with premolar and molar teeth with no furcation involvement
3. No systemic disease
4. Not under any medication which effect the outcome of periodontal therapy

Exclusion criteria

1. History of any periodontal therapy within past 6 months
2. Pregnant and lactating mothers
3. Smokers smoking >10 cigarettes per day
4. Patients with blood disorders or platelet count less than 50000 cells/ µL
5. Patients with known systemic disease
6. Non-compliant patients

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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48 participants in 2 patient groups

Probing sites with SPR and C-PRF application

Experimental group

Description:

The test group received the C-PRF as adjunct to sacling and root planing

Treatment:

Biological: C-PRF

Probing sites with SPR alone

No Intervention group