Concomitant Chemoradiotherapy With Weekly Paclitaxel and Vinorelbine and Granulocyte Colony Stimulating Factor (GCSF) Support in Patients With Advanced Breast Cancer

The University of Chicago

Status and phase

Completed

Phase 1

Conditions

Breast Cancer

Treatments

Drug: Vinorelbine

Drug: Filgrastim

Radiation: Radiation

Drug: Paclitaxel

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT00724386

UCIRB 9849

Details and patient eligibility

About

The goal of this study is to determine the feasibility based on toxicity and response rate of giving paclitaxel weekly with concomitant every-other week radiotherapy to limit skin toxicity. This study will also seek to determine the maximally tolerated dose of Navelbine added to this combination when followed by Filgrastim and the dose-limiting toxicities of this regimen.

Enrollment

26 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Histologically or cytologically confirmed adenocarcinoma of the male or female breast (male or female) with gross, uncontrolled, unresectable breast and/or chest wall disease including:
1. patients with locally advanced unresectable stage IIIa or IIIb;
2. patients with locally recurrent (including locoregional lymph nodes) disease for which curative surgery is not thought possible
3. patients with metastatic disease AND uncontrolled locoregional disease are eligible.
Prior chemotherapy allowed, except for nitrosoureas and mitomycin chemotherapy or high dose chemotherapy with marrow or stem cell rescue.
Prior palliative radiation to sites of metastases allowed (i.e. bone, brain, lung)
4 weeks since any prior treatments (excluding hormonal therapy). Concurrent hormonal therapy is not allowed.
Aged 18 years or older
CALGB performance status of 0 - 2
Life expectance of at least 12 weeks
Initial Laboratory Data:
- ANC Count > 1500/mm3
- Platelet Count > 100,000/mm3
- Creatine ≤ 2.0 mg/dl
- Bilirubin ≤ 1.5 mg/dl
- ALT (SGPT) ≤ 3 times the upper limit of normal
Signed informed consent

Exclusion criteria

Prior breast or chest wall radiation is not allowed unless the proposed site radiation port does not overlap with prior ports
Subjects must not be pregnant (females able to have children must have negative pregnancy test and agree to use adequate contraception)
Patients with a documented hypersensitivity to E.coli derived proteins are excluded.
No other serious medical condition such as uncontrolled infection that in the opinion of the investigators places patient at undue risk for study treatment