Concurrent Chemotherapy for Elderly Patients With Locoregionally Advanced Nasopharyngeal Carcinoma

University of Chinese Academy Sciences

Status and phase: Unknown; Phase 2

Conditions: Nasopharyngeal Carcinoma

Treatments: Radiation: Concurrent chemoradiotherapy; Radiation: Radiotherapy alone

Study type: Interventional

Funder types: Other

Identifiers

NCT03058432

ZJCH-2016-HN03

Details and patient eligibility

About

Concurrent Chemotherapy for Elderly Patients With Locoregionally Advanced Nasopharyngeal Carcinoma

Full description

To evaluate concurrent chemotherapy for elderly patients with locoregionally advanced nasopharyngeal carcinoma treated by intensity-modulated radiotherapy

Enrollment: 122 estimated patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Previously untreated and histologically confirmed locoregionally advanced nasopharyngeal carcinoma

Exclusion criteria

• A history of another invasive cancer, prior RT to the head and neck area, prior cytotoxic chemotherapy or anti-EGFR therapy or the presence of any serious medical conditions,supposed to live less than 6 months.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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122 participants in 2 patient groups

Intensity-modulated Radiotherapy

Experimental group

Description:

Radiotherapy alone was given.

Treatment:

Radiation: Radiotherapy alone

Concurrent chemoradiotherapy

Active Comparator group

Description:

Concurrent cisplatin-based radiotherapy was given.

Treatment:

Radiation: Concurrent chemoradiotherapy