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About
The purpose of this study is to evaluate the safety of combining chemotherapy at different doses with a specific type of radiation therapy delivered to the entire lining of the lung to find out what effects, if any, it has on people. This radiation technique is called pleural intensity modulated radiation therapy (IMRT). IMRT specifically targets the lining of the lung (pleura) where the cancer is and reduces the risk of damaging the lung itself. When given after chemotherapy, pleural IMRT has demonstrated promising results with respect to keeping mesothelioma under control longer. However, the investigators want to determine if giving pleural IMRT at the same time as chemotherapy is safe. If safe, further studies will be done to see if chemotherapy and pleural IMRT given at the same time keeps the tumor under control for a longer period of time than chemotherapy followed by pleural IMRT.
Sex
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Volunteers
Inclusion criteria
Pathologically confirmed diagnosis of malignant pleural mesothelioma at MSKCC
No plans for surgical resection
Stage T1-4, N0-3, M0
No prior radiation therapy to the chest, breast or supraclavicular fossa that would limit radiation delivery to the full prescription dose
Prior chemotherapy regimens ≤1
Age ≥18 years
Karnofsky performance status ≥ 80%
Pulmonary function tests as follows: DLCO>50% predicted
Adequate hematologic, hepatic, and renal function as indicated by the following laboratory values
Exclusion criteria
Primary purpose
Allocation
Interventional model
Masking
0 participants in 1 patient group
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Data sourced from clinicaltrials.gov
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