Conditioning Regimen Before Infusion of Allogeneic Hematopoietic Stem Cells

Cooperative Study Group A for Hematology

Status: Completed

Conditions: HEMATOLOGIC MALIGNANCIES

Study type: Observational

Funder types: NETWORK

Identifiers

NCT00770523

C-004

Details and patient eligibility

About

Unrelated Donor Hematopoietic Stem Cell Transplantation After Nonmyeloablative Conditioning for Younger Patients with Hematologic Malignancies.

Full description

Primary end points are treatment-related mortality and engraftment. Secondary end points are regimen-related toxicities, graft-versus-host-disease, relapse, and overall survival.

Enrollment: 52 patients

Sex: All

Ages: 15 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

-Patients should have an unrelated donor who is matched for HLA-A and -B by serology and for -DRB1 by molecular typing.

Exclusion criteria

• Patients should not have major illness or organ failure
• Patients must not have a psychiatric disorder or mental deficiency severe as to make compliance with the treatment unlike, and making informed consent impossible.
• Patients must not be pregnant or lactating.