CONDOR Study of Osteonecrosis of the Jaws (TMJ)

Dental Practice-Based Research Network

Status: Completed

Conditions: Osteonecrosis of the Jaw

Study type: Observational

Funder types: Other; NETWORK; NIH

Identifiers

NCT01130389

106037

U01DE016747 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The purpose of this study was to examine risk factors for osteonecrosis of the jaw (ONJ), including the possible association with bisphosphonates (BPs). This study used the research infrastructure from the three NIDCR-funded dental practice-based research networks (DPBRN, PEARL, PRECEDENT). De-identified data from the DPBRN were merged with comparable de-identified data from PEARL and PRECEDENT to form a single trans-PBRN data set used for analysis.

Full description

The aims of this study were to (1) test the hypothesis that (BP) treatment is a risk factor for (ONJ); (2) to test the hypothesis that dental diseases (particularly periodontal disease), and invasive dental procedures such as dental extractions are true risk factors for (ONJ).

Enrollment: 309 patients

Sex: All

Ages: 40+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• participants directly involved in this study were patients of dentists from the dental practice based research networks (DPBRN, PEARL, PRECEDENT).

Exclusion criteria

• participants with a history of sickle cell anemia
• participants with a history of external severe trauma to the jaws