Cone Beam CT for Daily Image Guidance - Prostate Cancer

University Health Network, Toronto

Status and phase: Completed; Phase 2

Conditions: Prostatic Neoplasms

Treatments: Procedure: daily Cone Beam CT for imaging guidance for radiotherapy

Study type: Interventional

Funder types: Other

Identifiers

NCT00188786

UHN REB 05-0037-C

Details and patient eligibility

About

Conformal dose escalated radiation therapy (CRT) is standard treatment for patients with low and intermediate risk prostate cancer. CRT requires accurate daily localization of the prostate prior to treatment to correct for prostate motion and set-up errors. Cone beam computed tomography (CT) can accurately localize fiducial markers within the prostate. Cone Beam CT also provides important information on daily position of organs within the pelvis. This study aims to assess the feasibility of cone beam CT for daily localization of the prostate as well as document changes in size and location of pelvic organs during an entire course of CRT.

Enrollment: 30 estimated patients

Sex: Male

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of adenocarcinoma of the prostate
• Patient undergoing dose escalated conformal external beam radiation therapy
• Low or intermediate risk prognostic factors (PSA 20 or less, Gleason score <8, Clinical T category <T3, Clinical N category 0 or X, M category 0 or X
• Age 18 years or older
• ECOG performance status 0 or 1
• Informed consent

Exclusion criteria

• Inflammatory bowel disease or collagen vascular disease

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)