Confocal Laser Endomicroscopy in Patients With Eosinophilic Esophagitis

University of Erlangen-Nürnberg Medical School

Status: Completed

Conditions: Eosinophilic Esophagitis

Treatments: Device: Confocal laser endomicroscopy

Study type: Observational

Funder types: Other

Identifiers

NCT01234376

HN-0003

Details and patient eligibility

About

Confocal laser endomicroscopy enables in vivo microscopic imaging within the mucosa layer of the gut at a subcellular resolution. Various studies have addressed the potential of endomicroscopy for the in vivo diagnosis of esophageal squamous cell carcinoma, Barrett´s esophagus and esophageal adenocarcinoma. Currently, there is only one case report from our group who noted the utility of endomicroscopy for the in vivo diagnosis of eosinophilic esophagitis.

The purpose of this study is to determine whether endomicroscopy is effective for the in vivo diagnosis of eosinophilic esophagitis.

Enrollment: 45 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Written informed consent
• Age 18-85 years
• Ability of subjects to understand character and individual consequences of clinical trial
• Subjects undergoing EGD

Exclusion criteria

• Inability to provide written informed consent
• Severe Coagulopathy (Prothrombin time < 50% of control, Partial thromboplastin time > 50 s)
• Impaired renal function (Creatinine > 1.2 mg/dl)
• Pregnancy or breast feeding
• Active gastrointestinal bleeding
• Known allergy to fluorescein, acriflavin or cresyl violet
• Residing in institutions (e.g. prison)

Trial design

45 participants in 2 patient groups

Control patients

Treatment:

Device: Confocal laser endomicroscopy

Patients with eosinophilic esophagitis

Treatment:

Device: Confocal laser endomicroscopy