Confocal Raman Spectroscopy: in Vivo Measurement of Physiological Skin Parameters

University of Vienna

Status: Completed

Conditions: Dermatologic Disorders; Disorder of Cholesterol Metabolism

Treatments: Procedure: Raman spectroscopy; Procedure: Venous blood collection

Study type: Interventional

Funder types: Other

Identifiers

NCT02854475

Raman 2016.1

Details and patient eligibility

About

The purpose of this study is to

I. determine several skin parameters, for example natural moisturizing factor (NMF) and cholesterol, with Raman spectroscopy in vivo and

II. compare the results with the corresponding cholesterol levels measured in venous blood.

Full description

In vivo Raman experiments will be carried out weekly on voluntary participants using a RiverDiagnostics gen2-SCA Skin Composition Analyzer (RiverDiagnostics, Rotterdam, Netherlands). All experiments will be carried out on the volar forearm. Semi-quantitative concentration profiles for several skin parameters will be determined, for example natural moisturizing factor (NMF) and cholesterol.

Additionally the total cholesterol level will be detected by venous blood sample analysis. The blood samples will be taken weekly within two weeks, similar to the Raman measurements.

Enrollment: 15 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Provision of subject informed consent
• Female or male aged between 18 and 65 years

Exclusion criteria

• Pregnancy
• Chronic skin conditions

Trial design

15 participants in 1 patient group

Proband group

Experimental group

Description:

Raman spectroscopy and venous blood collection

Treatment:

Procedure: Venous blood collection

Procedure: Raman spectroscopy