Confusion in the Elderly After Colon Surgery

New York Hospital Queens

Status: Unknown

Conditions: Acute Phase Reaction; Inflammation; Delirium; Surgery; Confusion

Study type: Observational

Funder types: Other

Identifiers

NCT01623297

ECRIP

Details and patient eligibility

About

A study will be conducted to determine if there is any cognitive benefit in elderly patients having open versus minimally invasive colon cancer surgery.

Full description

Cognitive changes in the elderly are common after surgery. It is not known if minimally invasive or laparoscopic surgery can prevent these changes. A study will be conducted on patients scheduled to have abdominal surgery. The patients will have cognitive evaluations before and after surgery. A small amount of blood, about 2 tablespoons, will be collected no more than 5 times in 6 months. The results will be analyzed to determine if there are changes between those having open surgery versus patients having laparoscopic or minimally invasive surgery, and if these changes coincide with cognitive changes.

Enrollment: 52 estimated patients

Sex: All

Ages: 65+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients over age 65.0 years and in need of elective colon resection for adenocarcinoma

Exclusion criteria

• Inability to complete preoperative cognitive screening
• Inability to complete study in English since CANTAB is timed and not validated with interpreters
• Emergency surgery
• Depression or psychiatric comorbidity
• Pre-existing dementia
• Previous cerebrovascular accident or "stroke"
• Previous myocardial infarction
• Cardiac ejection fraction below 55%
• Propranolol, metoprolol or other betablocker use
• Digoxin, procainamide, or amiodarone use
• Calcium channel blocker use
• History of vascular surgery or arterial vascular disease
• History of alcohol dependence
• Lovastatin or other HMG-CoA reductase inhibitor use
• Ace inhibitor use
• Neuroendocrine or catecholamine associated tumors
• Hypertension
• Diabetes
• Benzodiazepine use
• Dimenhydrinate or other medications to treat motion sickness
• Metaclopramide use

Trial design

52 participants in 2 patient groups

Laparoscopic colon surgery

Description:

Patients over age 65 having laparoscopic colon resection for colonic adenocarcinoma

Open colon surgery

Description:

Patients over age 65 having open colon resection for colonic adenocarcinoma